Aquaporins in spinal cord injury: the janus face of aquaporin 4
نویسندگان
چکیده
منابع مشابه
Aquaporin-4 and spinal cord injury
Edema formation is a major problem following traumatic spinal cord injury (SCI) that acts to exacerbate secondary damage. Severity of edema correlates with reduced neurological outcome in human patients. To date, there are no effective treatments to directly resolve edema within the spinal cord. The aquaporin-4 (AQP4) water channel is found on membranes of astrocytic endfeet in direct contact w...
متن کاملProtective role of aquaporin-4 water channels after contusion spinal cord injury.
OBJECTIVE Spinal cord injury (SCI) is accompanied by disruption of the blood-spinal cord barrier and subsequent extravasation of fluid and proteins, which results in edema (increased water content) at the site of injury. However, the mechanisms that control edema and the extent to which edema impacts outcome after SCI are not well elucidated. METHODS Here, we examined the role of aquaporin-4 ...
متن کاملMethylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema
Spinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in the acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid that has anti-inflammatory effects; however, its efficacy remains controversial. Although MP has been thought to help in the resolution of edema, there are ...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2010
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2010.01.037